Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety

cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety

the 1,4-dihydropyridine (dhp) derivatives are a known class of calcium channel blockers. some derivatives of dhp showed significant cytotoxicity. it was shown that this effect may not be the result of interaction with ca2+ channels. in this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of dhp containing nitroimidazole moiety on their c4 position on fo...

Synthesis of new 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone moiety containing 4-thiazolidinone moiety

A series of novel 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone framework (4a-f) were synthesized through a four-step reaction starting from the reduction of nitro derivatives of 1, 8-dioxo-octahydroxanthenes. The resulting aminoxanthenes converted to thiourea derivatives via their reaction with methyl isothiocyanate. The final products were synthesized through the re...

Synthesis and Biological Studies of Some New Chalcone and 1,4 -Dihydropyridine Derivatives Containing Phenothiazine Moiety

Anticonvulsant Effects of New 1, 4-Dihydropyridine Derivatives Containing Imidazolyl Moiety Against Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Mice

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,5-dicarboxamides was performed.Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetr...